Ekstra kurikuler di SMPK Santa Maria 2:
- Pramuka (wajib)
- Bola Basket
- Futsal
- Wushu
- Band
- Paduan Suara
- Art Corner
- Tradisional Dance
- Modern Dance
- Fashion
- Jurnalistik
- Teater
- Marching Band
- Club Olimpiade Matematika
- Club Matematika
- Club IPA
- Club IPS
- Club Komputer
- Palang Merah Remaja